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Vector Surveillance and Resistance Monitoring

Vector Surveillance and Resistance Monitoring

173 - Evaluation of a non-pyrethroid botanical molecule derived from Pogostemon cablin oil as a spatial repellent.

Wednesday, March 5, 2025
2:45 PM – 2:55 PM AST
Location: 208 A
Abstract: Unfortunately, resistance to pyrethroids is becoming ever more prevalent and is pervasive in some localities where vector-borne disease is endemic and suggests that these compounds may not be effective indefinitely, and worryingly might not remain efficacious even in the near future. To address this, we have been exploring the potential of a novel botantical compound from patchouli oil, that has been shown to be highly active as a repellent/insecticide in our laboratory. To do this, we have evaluated it as a spatial repellent in both laboratory and semi-field environments. Thus far, we have demonstrated that this molecule significantly repellent against laboratory-reared Aedes aegypti mosquitoes. Moreover, we have demonstrated that no cross resistance exists in a pyrethroid-resistant strain. Finally, we have begun exploring its potential as a spatial repellent in a semi-field environment, with results indicating that it is capable of producing pronounced knockdown effects. As part of a Department of Defense-funded project, we intend to continually evaluate the potential of this compound and deploy it in a variety of devices. This work has the potential to demonstrate the utility of non-pyrethroid compounds as viable spatial repellents for the control of various mosquito species.